INFECTIONS & INFESTATIONS
Bacterial infections 11A
respiratory or severe ENT, skin, or genitourinary:
875mg every 12hrs or 500mg every 8hrs.
Gonorrhea: 3g once. Severe renal impairment (CrCl
;30mL/min): 875mg tabs not recommended;
CrCl 10–30mL/min: 250–500mg every 12hrs;
CrCl ;10mL/min: 250–500mg every 24hrs (give
additional doses during and after hemodialysis).
Children: For treating acute otitis media: The
AAP recommends 80–90mg/kg per day in divided
doses (note: this is not an FDA-approved dose).
Do not exceed recommended adult dose. ;40kg:
dose as adults. Neonates and infants ;3months:
max 30mg/kg per day in divided doses every
12hrs. ;3months: Mild to moderate ENT, skin, or
genitourinary: 25mg/kg per day in divided doses
every 12hrs or, 20mg/kg per day in divided doses
every 8hrs. Lower respiratory or severe ENT, skin,
or genitourinary: 45mg/kg per day in divided doses
every 12hrs or, 40mg/kg per day in divided doses
every 8hrs. Gonorrhea: ;2yrs: not recommended;
;2yrs: 50mg/kg with 25mg/kg probenecid once.
Renal dysfunction: not recommended.
Warnings/Precautions: Cephalosporin, imipenem,
other allergy or mononucleosis: not recommended.
Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy (Cat.B).
Nursing mothers.
Interactions: Potentiated by probenecid. May cause
false (;) glucose test with Clinitest, Benedict’s or
Fehling’s soln.
Adverse reactions: GI upset, hypersensitivity
reactions (eg, urticaria, rash, Stevens-Johnson
syndrome, anaphylaxis), hyperactivity, blood
dyscrasias.
How supplied: Caps–500; Susp
250mg/5mL–100mL, 150mL; Susp
400mg/5mL–100mL; Drops 50mg/mL–30mL
; AMOXICILLIN ; CLAVULANIC
ACID
AUGMENTIN XR GlaxoSmithKline
Broad-spectrum penicillin ; ;-lactamase inhibitor.
Amoxicillin 1000mg, clavulanic acid (as potassium)
62.5mg; scored ext-rel tabs.
Indications: Susceptible infections including
community-acquired pneumonia and acute bacterial
sinusitis (see literature).
Adults: Take with meals. May split scored tabs; do
not reduce dose. Two Augmentin 500mg tabs are
not equivalent to one XR tab. ;16yrs: 2 tabs every
12 hrs. Sinusitis: treat for 10 days. CAP: treat for
7–10 days.
Children: ;16yrs: not recommended.
Also: Amoxicillin ; Clavulanic acid
AUGMENTIN 250
Amoxicillin 250mg, clavulanic acid (as potassium)
125mg; tabs.
Also: Amoxicillin ; Clavulanic acid
AUGMENTIN 500
Amoxicillin 500mg, clavulanic acid (as potassium)
125mg; tabs.
;
;
; Also: Amoxicillin ; Clavulanic acid
AUGMENTIN 875
