IMMUNE SYSTEM
Immunization 10A
Adverse reactions: Local reactions,
lymphadenopathy, headache, myalgia, malaise,
dizziness, neuroparalytic events, anaphylaxis.
How supplied: Single-dose vial– 1 (w. diluent)
; ROTAVIRUS VACCINE
ROTATEQ Merck
Pentavalent, live rotavirus vaccine; oral susp;
contains fetal bovine serum (trace); preservative- and
thimerosal-free.
Indications: Rotavirus gastroenteritis vaccination in
infants 6–32 weeks of age.
Adults: Not recommended.
Children: ;
6 weeks or ;
32 weeks: not
recommended. Each dose is 1 tube. Give 1st dose
orally at 6–12 weeks of age; give 2nd and 3rd dose
at 4–10 week intervals for a total of 3 doses. If
incomplete dose is given, do not give replacement
dose; continue with remaining doses in the
recommended series.
Warnings/Precautions: Immunocompromised.
Febrile illness. Active or history of GI disorders.
Chronic diarrhea. Failure to thrive. History of
congenital abdominal disorders. Abdominal surgery.
Intussusception. Immunodeficient close contacts.
Interactions: Immunosuppressants (eg, irradiation,
chemotherapy, high-dose steroids): may get
suboptimal response. Concomitant vaccines: see
literature; oral polio vaccine: not recommended.
Adverse reactions: Diarrhea, vomiting, otitis
media, nasopharyngitis, bronchospasm; rare:
intussusception, hematochezia, seizures, Kawasaki
disease.
How supplied: Single-use tube (2mL)– 1, 10
; TETANUS TOXOID
TETANUS TOXOID ADSORBED Sanofi Pasteur
Tetanus vaccine. Tetanus toxoid; aluminum adsorbed;
susp for IM inj; multi-dose vial preserved with
thimerosal, single-dose vials contain trace amounts
of thimerosal.
Indications: Tetanus immunization.
Adults and Children: ;7yrs: not recommended.
Give IM in anterolateral thigh or deltoid. ;7yrs:
Previously unvaccinated: three 0.5mL doses at
elected date, then 4–8 weeks after first dose, and
6–12 months after second dose. Give booster dose
at 11–12 yrs of age if last dose of tetanus and
diphtheria toxoid-containing vaccine was given ;5yrs
ago. Other: give booster every 10 years.
Warnings/Precautions: Latex allergy. Previous
arthus-type hypersensitivity reaction: do not give more
frequently than every 10 years. Defer in moderate
or severe active respiratory or other febrile infection
(may vaccinate if mild or minor illness) or during
polio outbreak. Guillain-Barre syndrome within 6
weeks of last tetanus vaccine. Bleeding disorders.
Immunosuppressed. Have epinephrine (1:1000)
available. Elderly. Pregnancy (Cat.C). Nursing mothers.
Interactions: May get suboptimal response with
immunosuppressants (eg, chemotherapy, high dose
corticosteroids ;
2 weeks, radiation); consider
deferring.
Adverse reactions: Local reactions (eg, erythema,
tenderness), malaise, fever, hypotension, pain,
nausea, arthralgia; rare: neurological disorders.
How supplied: Single-dose vials (latex free)– 10
Multi-dose vial (5mL)– 1
; TETANUS TOXOID
TETANUS TOXOID BOOS TER Sanofi Pasteur
Tetanus vaccine. Tetanus toxoid booster vaccine; for
IM or SC inj; contains thimerosal.
Indications: Tetanus immunization booster.
Adults and Children: ;7yrs: not recommended.
Give IM or SC in lateral mid-thigh or deltoid. ;7yrs:
After completion of primary immunization: 0.5mL
every 10 years. Tetanus prophylaxis: see literature.
Contraindications: Not for primary immunization.
History of systemic allergic or neurologic reactions to
a previous dose of DT.
Warnings/Precautions: Latex allergy. Previous
arthus-type hypersensitivity reaction: do not give
more frequently than every 10 years. Defer in
moderate or severe active respiratory or other febrile
infection (may vaccinate if mild or minor illness) or
during polio outbreak. Bleeding disorders (use SC
route). Immunosuppressed. History of Guillain-Barre
syndrome within 6 weeks of last tetanus vaccine.
Have epinephrine (1:1000) available. Elderly.
Pregnancy (Cat.C). Nursing mothers.
Interactions: May get suboptimal response with
immunosuppressants (eg, chemotherapy, high dose
corticosteroids ;
2 weeks, radiation); consider
deferring.
Adverse reactions: Local reactions (eg, erythema,
tenderness), malaise, fever, hypotension, pain,
nausea, arthralgia; rare: neurological disorders.
How supplied: Vial ( 7.5mL)– 1
; TETANUS TOXOID ;
DIPHTHERIA TOXOID
DECAVAC Sanofi Pasteur
Td vaccine. Tetanus and diphtheria toxoids; aluminum
adsorbed; susp for IM inj; contains thimerosal (trace).
Indications: Tetanus and diphtheria immunization in
patients ;7yrs.
Adults and Children: ;7yrs: not recommended.
;7yrs: Give IM in deltoid muscle. Previously
unvaccinated: three 0.5mL doses at elected date,
then 4–8 weeks after first dose, and 6–12 months
after second dose. Give booster dose at 11–12 yrs
of age if last dose of tetanus and diphtheria toxoid-containing vaccine was given ;5yrs ago. Other:
give booster every 10 years. Diphtheria and tetanus
prophylaxis: see literature.
Contraindications: Anaphylaxis associated with a
previous dose.
Warnings/Precautions: Guillain-Barre syndrome
within 6 weeks of previous tetanus toxoid vaccine.
Previous Arthus-type hypersensitivity reaction: not
recommended until ;10yrs after prior dose of
