EYE DISORDERS
Glaucoma 7B
reactions or pruritus, corneal staining/erosion,
photophobia, ocular discomfort or dryness, tearing,
upper respiratory symptoms, conjunctival blanching,
muscular pain, others.
How supplied: Soln–5mL, 10mL, 15mL
;BRINZOLAMIDE
AZOPT Alcon
Carbonic anhydrase inhibitor (sulfonamide).
Brinzolamide 1%; oph. susp; contains benzalkonium
chloride.
Indications: Open-angle glaucoma. Ocular
hypertension.
Adults: 1 drop 3 times daily.
Children: Not recommended.
Warnings/Precautions: Hepatic impairment.
Severe renal impairment (CrCl ;30mL/min): not
recommended. Discontinue if serious systemic,
ocular (eg, conjunctivitis, lid edema), or
hypersensitivity reactions occur. Soft contact
lenses (remove; may reinsert 15 minutes after
administration). Pregnancy (Cat.C). Nursing mothers:
not recommended.
Interactions: Concomitant oral carbonic anhydrase
inhibitors: not recommended. Separate administration
of other oph drugs by ;
10 minutes.
Adverse reactions: Blurred vision, bitter/sour
taste, blepharitis, dermatitis, dry eye, foreign body
sensation, headache, hyperemia; ocular discharge,
discomfort, or itch; keratitis, rhinitis.
How supplied: Susp– 2.5mL, 5mL, 10mL, 15mL
; DORZOLAMIDE ; TIMOLOL
COSOPT Merck
Carbonic anhydrase inhibitor (sulfonamide) ;
noncardioselective ;-blocker. Dorzolamide HCl
2%, timolol maleate 0.5%; oph soln; contains
benzalkonium chloride.
Indications: Open-angle glaucoma or ocular
hypertension where ;-blocker alone is inadequate.
Adults: 1 drop twice daily.
Children: Not recommended.
Contraindications: Asthma or history of asthma.
Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV
block. Overt cardiac failure. Cardiogenic shock.
Warnings/Precautions: Mild-to-moderate COPD or
bronchospastic disease, or severe renal impairment:
not recommended. Hepatic impairment. Surgery. May
mask hypoglycemia or thyrotoxicosis. Myasthenia
gravis. Discontinue if ocular effects occur. Soft
contact lenses (remove, may reinsert 15 minutes
after instillation). Discontinue at 1st sign of cardiac
failure. Pregnancy (Cat.C). Nursing mothers: not
recommended.
Interactions: Concomitant oral carbonic
anhydrase inhibitors or other topical ;-blockers: not
recommended. May potentiate systemic ;-blockers,
reserpine, hypoglycemic agents, and mydriatic
effects of topical epinephrine. May be potentiated by
quinidine. May inhibit renal excretion of basic drugs
and promote excretion of acidic drugs. May increase
salicylate toxicity (acidosis). Possible conduction
defects, left ventricular failure, or hypotension
with calcium channel blockers, digoxin. May block
epinephrine.
Adverse reactions: Taste perversion; ocular
burning, stinging, or itching; conjunctival hyperemia,
blurred vision, superficial punctate keratitis; possible
systemic effects.
How supplied: Soln–10mL
;LATANOPROST
XALATAN Pfizer Ophthalmics
Prostanoid. Latanoprost 0.005%; oph soln; contains
benzalkonium chloride.
Indications: Open-angle glaucoma. Ocular
hypertension.
Adults: 1 drop once daily in the PM.
Children: Not recommended.
Warnings/Precautions: Do not exceed
recommended dose (may reduce efficacy). Ocular
inflammation. Aphakia. Pseudophakia with torn
posterior lens capsule. Risk of macular edema.
Contact lenses (remove; may reinsert lenses
15 minutes after administration). Pregnancy (Cat.C).
Nursing mothers.
Interactions: Allow at least 5 minutes between
application of other topical oph agents.
Adverse reactions: Blurred vision, burning,
stinging, conjunctival hyperemia, foreign body
sensation, itching, other local reactions, increased
ocular pigmentation (eg, iris, eyelid, eyelashes; may
be permanent), other eyelash changes, punctate
epithelial keratopathy, photophobia, upper
respiratory tract infection, pain, angina, rash,
macular edema.
How supplied: Soln– 2.5mL
;TIMOLOL
TIMOPTIC Aton
Noncardioselective ;-blocker. Timolol (as maleate)
0.25%, 0.5%; oph soln; contains benzalkonium
chloride.
; Also: Timolol
TIMOPTIC OCUDOSE
Timolol (as maleate) 0.25%, 0.5%; (0.2mL/dose); oph
soln; preservative-free.
Indications: Open-angle glaucoma.
Adults: Initially 1 drop of 0.25% twice daily; max 1
drop of 0.5% twice daily. Transfer from other drugs,
see literature.
Children: Not recommended.
; Also: Timolol
TIMOPTIC-XE
Timolol maleate 0.25%, 0.5%; oph gel forming soln.
Adults: Invert closed bottle and shake once before
each use. 1 drop once daily. Give other oph. drugs at
least 10 minutes before.
Children: Not recommended.
Contraindications: Greater than 1st-degree AV
block. Uncompensated cardiac failure. Cardiogenic
