EYE DISORDERS
6E/Ocular infections 7A
air way obstruction or sleep apnea occur. Not for use
in patients with functioning renal allografts. History
of intracranial lesions: monitor for lesion progression
or recurrence. Scoliosis. Obtain baseline hip X-ray
and monitor for renal osteodystrophy in renal failure.
Monitor for otitis media, other ear disorders, and
cardiovascular disorders in Turner syndrome. May
elevate serum phosphate, alkaline phosphatase,
parathyroid hormone. Elderly. Pregnancy (Cat.C).
Nursing mothers.
Interactions: May be antagonized by
glucocorticoids. May affect CYP3A4 substrates.
Adverse reactions: Local reactions, intracranial
hypertension, slipped capital epiphysis, antibody
formation, edema, arthralgia, carpal tunnel syndrome,
gynecomastia.
How supplied: Nutropin vial– 2 (w. diluent)
Nutropin AQ (2mL) vial– 1
Nutropin AQ (2mL) pen– 1
;SOMATROPIN
TEV-TROPIN Teva
Growth hormone (GH). Somatropin (rDNA origin) 5mg
( 15 IU); pwd for SC inj after reconstitution; contains
mannitol; diluent contains benzyl alcohol.
Indications: Growth failure in children due to
inadequate endogenous GH secretion.
Adults: Not recommended.
Children: Individualize. Give by SC inj up to
0.1mg/kg 3 times per week; rotate inj site.
Contraindications: Acute critical illness. Acute
respiratory failure. Closed epiphyses. Active
malignancy or growing intracranial tumors. Diabetic
retinopathy. Prader-Willi syndrome (severely obese or
w. respiratory impairment); see literature.
Warnings/Precautions: Monitor gait, thyroid
function, glucose tolerance, for malignant
transformation of skin lesions, and for intracranial
hypertension (do baseline and periodic funduscopic
exams). History of intracranial lesions: monitor
for lesion progression or recurrence. Prader-Willi
syndrome: evaluate baseline respiratory function;
monitor weight and for respiratory infection.
Discontinue if signs of upper air way obstruction
or sleep apnea occurs. Diabetes. Hypothyroidism.
Scoliosis. Turner syndrome: evaluate for ear
disorders (eg, otitis media); monitor for
cardiovascular disorders (eg, stroke, aortic
aneurysm/dissection, hypertension). Pregnancy
(Cat.C). Nursing mothers.
Interactions: Antagonized by glucocorticoids.
Antidiabetic medications may need to be adjusted.
May affect CYP3A4 substrates.
Adverse reactions: Headache, inj site reactions,
localized muscle pain, weakness, hypothyroidism,
mild hyperglycemia, glucosuria, arthralgia, myalgia,
fluid retention, edema, elevated serum phosphate,
antibody formation, pancreatitis; also children:
slipped capital femoral epiphysis. Long-term overdose
may cause gigantism and/or acromegaly.
How supplied: Vials (5mg)– 1 (w. diluent)
;CIPROFLOXACIN
CILOXAN Alcon
Quinolone. Ciprofloxacin (as HCl) 0.3%; oph. soln;
contains benzalkonium chloride.
Indications: Susceptible infections of conjunctiva
and cornea.
Adults and Children: ;
1 year: not
recommended. ;
1 year: Conjunctivitis: 1–2 drops
in conjunctival sac(s) every 2 hours while awake for
2 days, then 1–2 drops every 4 hours while awake
for next 5 days. Corneal ulcers: 2 drops every 15
minutes for 1st 6 hours, then 2 drops every 30
minutes for rest of 1st day; 2nd day: 2 drops every 1
hour; 3rd–14th days: 2 drops every 4 hours. May treat
for 14 days or until corneal reepithelialization occurs.
; Also: Ciprofloxacin
CILOXAN OPHTHALMIC OINTMENT
Ciprofloxacin (as HCl) 0.3%.
Indications: Bacterial conjunctivitis.
Adults and Children: ;
2 years: not
recommended. ;
2 years: ½ inch into conjunctival sac
3 times daily for 2 days, then twice daily for 5 days.
Warnings/Precautions: CNS or convulsive
disorders. Discontinue if rash occurs. Pregnancy
(Cat.C). Nursing mothers.
Interactions: May increase theophylline levels. May
potentiate oral anticoagulants. May increase renal
toxicity with cyclosporine.
Adverse reactions: Soln: Burning, crystalline
precipitates, lid margin crusting, scales, foreign body
sensation, pruritus, conjunctival hyperemia, bad
taste. Oint: ocular discomfort, blurred vision; may
delay corneal healing. Both: superinfection.
How supplied: Soln– 2.5mL, 5mL, 10mL; Oint– 3.5g
;GATIFLOXACIN
ZYMAR Allergan
Quinolone. Gatifloxacin 0.3%; oph soln; contains
benzalkonium chloride.
Indications: Susceptible infections of the conjunctiva.
Adults and Children: ;1yr: not recommended.
;1yr: 1 drop every 2 hours while awake for 2 days
(up to 8 times daily), then 1 drop 4 times daily while
awake for 5 more days.
Warnings/Precautions: Discontinue if
superinfection or hypersensitivity occurs. Pregnancy
(Cat.C). Nursing mothers.
Interactions: May potentiate theophylline,
caffeine, oral anticoagulants, cyclosporine if systemic
absorption occurs.
Adverse reactions: Irritation, lacrimation, keratitis,
papillary conjuctivitis, chemosis, conjunctival
hemorrhage, dry or red eye, headache, blurred vision,
taste disturbances, superinfection, anaphylaxis.
How supplied: Soln–5mL
