ENDOCRINE SYSTEM
Hypogonadism 6D
Warnings/Precautions: Monitor blood.
Discontinue if hepatic dysfunction, agranulocytosis,
aplastic anemia, fever, or exfoliative dermatitis
occurs. Pregnancy (Cat.D).
Interactions: May potentiate anticoagulants.
Caution with other drugs that may cause
agranulocytosis.
Adverse reactions: Rash, urticaria, GI upset,
arthralgia, paresthesia, taste loss/perversion, hair
loss, myalgia, headache, drowsiness, edema, vertigo,
jaundice, blood dycrasias, lupus-like syndrome, drug
fever, hepatitis, hypoprothrombinemia.
How supplied: Tabs– 100, 1000
CIIIOXANDROLONE
OXANDRIN Savient
Androgen. Oxandrolone 2.5mg;, 10mg; tabs
(;scored).
Indications: As an adjunct to promote weight gain
after extensive surgery, chronic infections, severe
trauma, and without definite cause, to offset protein
catabolism associated with prolonged corticosteroid
administration, and for relief of osteoporotic bone
pain.
Contraindications: Male breast or prostate
carcinoma. Nephrosis. Hypercalemia. Pregnancy
(Cat.X).
Warnings/Precautions: Discontinue if jaundice,
abnormal liver function, hypercalcemia, or edema
occurs. Cardiac, hepatic, or renal dysfunction. Monitor
hepatic function, blood, and bone age. Elderly. Young
children. Nursing mothers: not recommended.
Interactions: May potentiate oral anticoagulants,
oxyphenbutazone. May alter insulin needs. Increased
risk of edema with ACTH, corticosteroids.
Adverse reactions: Peliosis hepatis, premature
epiphyseal closure in adolescents, edema, hepatic
carcinoma, prostatic hypertrophy or carcinoma,
gynecomastia, priapism, oligospermia, nausea,
jaundice, hirsutism, virilization, male pattern
baldness, acne, polycythemia, headache, anxiety,
depression, paresthesias, altered libido, fluid and
electrolyte disturbances, suppression of clotting
factors, increased serum cholesterol.
How supplied: Tabs 2.5mg– 100
10mg– 60
TESTOSTERONE
ANDROGEL 1% Abbott
Androgen. Testosterone 1%; gel.
Indications: Testosterone replacement therapy.
Adults: Advise patients to strictly adhere to
recommended instructions. Apply to clean, intact, dry
skin of the shoulders, upper arms, and/or abdomen;
do not apply to scrotum. ;18yrs: 5g (50mg of
testosterone) once daily in the AM; check serum
testosterone level at intervals until normal range;
may increase to 7.5g/day (75mg of testosterone),
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then to 10g/day (100mg of testosterone) if needed.
Wash hands after application. Allow gel to dry before
it touches clothing.
TESTOSTERONE CYPIONATE
DEPO-TESTOSTERONE Pfizer
Androgen. Testosterone cypionate 100mg/mL,
200mg/mL; IM inj in cottonseed oil; contains benzyl
alcohol.
Indications: Testosterone replacement therapy.
Adults: Give by deep IM inj into gluteal muscle once
every 2 to 4 weeks. 50–400mg; max 400mg/month.
Children: Not recommended.
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